Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:1221637 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12216371222491855hypothetical proteinBLASTP
122282912243551527aldehyde dehydrogenaseQuickGO ontologyBLASTP
122436912263151947thiamine pyrophosphate-dependent proteinQuickGO ontologyBLASTP
12266091227118510hypothetical proteinBLASTP
12270851227594510myo-inositol 2-dehydrogenaseQuickGO ontologyBLASTP
12277201228649930sugar-binding periplasmic proteinQuickGO ontologyBLASTP
122869812302451548sugar transport ATP-binding proteinQuickGO ontologyBLASTP
123025712312851029sugar transport system permease proteinQuickGO ontologyBLASTP
123130912324421134hypothetical proteinBLASTP
123247412344441971carbohydrate kinaseQuickGO ontologyBLASTP
123445912355171059hypothetical proteinBLASTP
12355271236342816hypothetical proteinBLASTP
12365451236847303hypothetical proteinBLASTP
123691212387021791ABC transport proteinQuickGO ontologyBLASTP
12387181239005288hypothetical proteinBLASTP
12394481239642195hypothetical proteinBLASTP
12396601239947288hypothetical proteinBLASTP
12400241240878855membrane proteinQuickGO ontologyBLASTP
12414121242029618LuxR-family regulatory proteinsQuickGO ontologyBLASTP
12423391242830492hypothetical proteinBLASTP
12430821243315234hypothetical proteinBLASTP