Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:3175692 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
317569231772121521hypothetical protein
31774383177695258hypothetical proteinBLASTP
31778003178111312hypothetical proteinBLASTP
317838431794631080tnpa proteinQuickGO ontologyBLASTP
317950931807651257transposaseQuickGO ontologyBLASTP
31836123183953342hypothetical proteinBLASTP
318395431849701017hypothetical proteinBLASTP
318498331861311149hypothetical proteinBLASTP
318622731873541128hypothetical proteinBLASTP
31873513188259909hypothetical proteinBLASTP
31882403188950711hypothetical proteinBLASTP
31889473189339393hypothetical proteinBLASTP
318933631917772442hypothetical proteinBLASTP
319281831939721155hypothetical proteinBLASTP
31944873195032546hypothetical proteinBLASTP
31953193195711393hypothetical proteinBLASTP
31957083195923216hypothetical proteinBLASTP
31959703196719750putative enoyl-CoA hydratase ECHA16QuickGO ontologyBLASTP
319673331978151083putative Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UGPCQuickGO ontologyBLASTP
319780831991181311putative Sn-glycerol-3-phosphate-binding lipoprotein UGPBQuickGO ontologyBLASTP