Pre_GI Gene

Some Help

Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1291754 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12917541292608855hypothetical proteinBLASTP
129294612944721527aldehyde dehydrogenaseQuickGO ontologyBLASTP
129452212964321911malonic semialdehyde oxidative decarboxylaseQuickGO ontologyBLASTP
12978191298748930periplasmic solute-binding protein of ABC transporterQuickGO ontologyBLASTP
129879713003441548ATP-binding component of D-ribose high-affinity transport systemQuickGO ontologyBLASTP
130035613013841029D-ribose high-affinity transport systemQuickGO ontologyBLASTP
130140513025411137hypothetical proteinBLASTP
130257313045431971myo-inositol catabolism protein iolBQuickGO ontologyBLASTP
130455813056161059myo-inositol catabolism protein iolBQuickGO ontologyBLASTP
13056261306441816myo-inositol catabolism protein iolBQuickGO ontologyBLASTP
13066001306803204hypothetical protein
13066441306946303hypothetical proteinBLASTP
130701113088011791ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
13088171309104288hypothetical proteinBLASTP
13095471309741195hypothetical proteinBLASTP
13097591309941183hypothetical proteinBLASTP
13101231311088966hypothetical proteinBLASTP
1310780131086990hypothetical protein
13115111312128618regulatory proteinQuickGO ontologyBLASTP
13124281312919492cold-shock proteinQuickGO ontologyBLASTP
13131411313395255cold shock protein EQuickGO ontologyBLASTP
13131711313404234hypothetical proteinBLASTP
13138181314207390camphor resistance protein CrcBQuickGO ontologyBLASTP