Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:3794000 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
379405537953951341hypothetical proteinBLASTP
379543737966121176putative trehalose-phosphataseQuickGO ontologyBLASTP
37968493797490642enoyl-CoA hydratase EchA18QuickGO ontologyBLASTP
37974913797739249enoyl-CoA hydratase EchA181QuickGO ontologyBLASTP
379774437991711428amidase AmiDQuickGO ontologyBLASTP
37992793799932654hypothetical proteinBLASTP
379997138014761506putative cyclaseQuickGO ontologyBLASTP
38014813802371891hypothetical proteinBLASTP
3802380380399016111-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
38042233805107885IS6110 transposaseQuickGO ontologyBLASTP
38051583805484327IS6110 hypothetical proteinQuickGO ontologyBLASTP
38055713806560990putative lytB-related protein LytB1QuickGO ontologyBLASTP
380656038076121053putative polyprenyl synthetase IdsBQuickGO ontologyBLASTP
38083663808758393hypothetical proteinBLASTP
38087583809066309hypothetical proteinBLASTP
38092153809919705putative transposaseQuickGO ontologyBLASTP
38099093810586678putative transposaseQuickGO ontologyBLASTP
381066838134692802hypothetical proteinBLASTP
381077638125241749PE-PGRS family proteinQuickGO ontologyBLASTP
38135433814253711putative lipoprotein LpqDQuickGO ontologyBLASTP
381429938162511953multi-functional enzyme with acyl-CoA-reductase activity AcrA1QuickGO ontologyBLASTP