Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:1629780 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
162978016313241545glucose-6-phosphate 1-dehydrogenaseQuickGO ontologyBLASTP
163132116324421122transaldolaseQuickGO ontologyBLASTP
163245916345612103transketolaseQuickGO ontologyBLASTP
163500016392234224PE-PGRS family proteinQuickGO ontologyBLASTP
16396251640551927cytochrome C oxidase assembly factor ctaBQuickGO ontologyBLASTP
164060016428132214PE-PGRS family proteinQuickGO ontologyBLASTP
164293216442301299hypothetical transcriptional activator proteinQuickGO ontologyBLASTP
16442581645244987quinone reductase qor NADPHquinone reductase zeta-crystallin proteinQuickGO ontologyBLASTP
16452641646127864hypothetical proteinBLASTP
16460771647009933hypothetical antibiotic-transport integral membrane ABC transporterQuickGO ontologyBLASTP
16471211647906786hypothetical antibiotic-transport integral membrane ABC transporterQuickGO ontologyBLASTP
16479031648844942hypothetical antibiotic-transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
164900016507751776conserved integral membrane proteinQuickGO ontologyBLASTP
16508231651629807hypothetical transcriptional regulatory proteinQuickGO ontologyBLASTP
165162616541662541hypothetical proteinBLASTP
165416316553561194hypothetical proteinBLASTP
16553531656153801ATP-binding protein ABC transporterQuickGO ontologyBLASTP