Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2895617 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28956172896471855hypothetical proteinBLASTP
289677728983031527putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
289831729002631947putative thiamine pyrophosphate-dependent proteinQuickGO ontologyBLASTP
29016682902597930putative sugar-binding periplasmic proteinQuickGO ontologyBLASTP
290264629041931548sugar transport ATP-binding proteinQuickGO ontologyBLASTP
290420529052331029sugar transport system permease proteinQuickGO ontologyBLASTP
290525729063901134hypothetical proteinBLASTP
290642229083921971putative carbohydrate kinaseQuickGO ontologyBLASTP
29085452909465921hypothetical proteinBLASTP
29094752910290816hypothetical proteinBLASTP
291075529126501896putative ABC transport proteinQuickGO ontologyBLASTP
29126662912953288hypothetical proteinBLASTP
29133962913590195hypothetical proteinBLASTP
29136082913790183hypothetical proteinBLASTP
29139722914937966hypothetical proteinBLASTP
29153602915977618putative LuxR-family regulatory proteinsQuickGO ontologyBLASTP
29162972916668372hypothetical proteinBLASTP
29170542917263210cold shock protein EQuickGO ontologyBLASTP
29176862918069384camphor resistance protein CrcBQuickGO ontologyBLASTP