Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:833076 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
833076833573498hypothetical transcriptional regulatory proteinQuickGO ontologyBLASTP
833931834479549hypothetical proteinBLASTP
834727835530804hypothetical proteinBLASTP
835564836172609hypothetical proteinBLASTP
836403836717315transposaseQuickGO ontologyBLASTP
836859837377519PE-PGRS family proteinQuickGO ontologyBLASTP
837755838312558hypothetical proteinBLASTP
838309838815507hypothetical transcriptional regulatory proteinQuickGO ontologyBLASTP
839023839550528hypothetical proteinBLASTP
8395708419212352PE-PGRS family proteinQuickGO ontologyBLASTP
8423208447252406PE-PGRS family proteinQuickGO ontologyBLASTP
844816845073258hypothetical proteinBLASTP
845097845525429hypothetical proteinBLASTP
845902846147246hypothetical proteinBLASTP
8462168471008853-hydroxyisobutyrate dehydrogenase mmsBQuickGO ontologyBLASTP
8471118482831173acyl-CoA dehydrogenase fadE9QuickGO ontologyBLASTP
8482908498221533methylmalonate-semialdehyde dehydrogenase mmsAQuickGO ontologyBLASTP
8500288517821755PE-PGRS family proteinQuickGO ontologyBLASTP