Pre_GI Gene

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Host: NC_002755 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002755:3773734 Mycobacterium tuberculosis CDC1551, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
377373437770303297DNA polymerase III subunit alphaQuickGO ontologyBLASTP
377716537785051341hypothetical proteinBLASTP
377854737797221176trehalose-phosphatase putativeQuickGO ontologyBLASTP
37797193779880162hypothetical proteinBLASTP
378085437822811428amidase family proteinQuickGO ontologyBLASTP
37823893783042654hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
378308137845861506cyclase putativeQuickGO ontologyBLASTP
37845913785481891hypothetical proteinBLASTP
37873233788312990lytB proteinQuickGO ontologyBLASTP
378831237893761065polyprenyl synthetaseQuickGO ontologyBLASTP
37898103789938129hypothetical protein
37901183790513396hypothetical proteinBLASTP
37905103790818309hypothetical proteinBLASTP
37909673791671705IS1560 transposaseQuickGO ontologyBLASTP
37916613792338678IS1560 transposaseQuickGO ontologyBLASTP
379239637947232328PE_PGRS family proteinQuickGO ontologyBLASTP
37947943795666873MaoC family proteinQuickGO ontologyBLASTP
37957403796450711lipoprotein putativeQuickGO ontologyBLASTP
379649637984481953short chain dehydrogenaseQuickGO ontologyBLASTP