Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:3793976 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
379397637972153240DNA polymerase III alpha subunit dnaE2 DNA nucleotidyltransferaseQuickGO ontologyBLASTP
379740737987471341hypothetical proteinBLASTP
379878937999641176trehalose 6-phosphate phosphatase otsB2QuickGO ontologyBLASTP
38002013800842642enoyl-CoA hydratase echA18QuickGO ontologyBLASTP
38008433801091249enoyl-CoA hydratase echA181QuickGO ontologyBLASTP
380109638025231428amidase amiD acylamidaseQuickGO ontologyBLASTP
38026313803284654hypothetical proteinBLASTP
380332338048281506hypothetical cyclaseQuickGO ontologyBLASTP
38048333805723891hypothetical proteinBLASTP
3805732380734216111-deoxy-D-xylulose 5-phosphate synthase dxs2QuickGO ontologyBLASTP
38075653808560996lytB-related protein lytB1QuickGO ontologyBLASTP
380855438096061053polyprenyl synthetase idsBQuickGO ontologyBLASTP
38103603810752393hypothetical proteinBLASTP
38107523811060309hypothetical proteinBLASTP
38112093811913705transposaseQuickGO ontologyBLASTP
38119033812580678transposaseQuickGO ontologyBLASTP
381277038149652196PE-PGRS family proteinQuickGO ontologyBLASTP
38150363815908873hypothetical dehydrogenaseQuickGO ontologyBLASTP
38159823816692711lipoprotein lpqDQuickGO ontologyBLASTP
381673838186901953multi-functional acyl-CoA-reductase acrA1QuickGO ontologyBLASTP