Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:3851230 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
385466038560001341hypothetical proteinBLASTP
385604238572171176putative trehalose 6-phosphate phosphatase OTSB2QuickGO ontologyBLASTP
38574543858095642putative enoyl-CoA hydratase ECHA18QuickGO ontologyBLASTP
38580963858344249putative enoyl-CoA hydrataseQuickGO ontologyBLASTP
385834938597761428putative amidase amidQuickGO ontologyBLASTP
38598843860537654hypothetical proteinBLASTP
386057738620821506putative cyclaseQuickGO ontologyBLASTP
38620873862977891hypothetical proteinBLASTP
386298638645961611putative 1-deoxy-D-xylulose 5-phosphate synthase DXS2QuickGO ontologyBLASTP
38648213865810990putative LYTB-like protein LYTB1QuickGO ontologyBLASTP
386581038668621053putative polyprenyl synthetase IDSBQuickGO ontologyBLASTP
386735338686211269putative transposaseQuickGO ontologyBLASTP
38690223869405384hypothetical proteinBLASTP
38694143869692279antitoxinQuickGO ontologyBLASTP
386986338711971335transposase for insertion sequence element is1557QuickGO ontologyBLASTP
38712493872121873putative dehydrogenaseQuickGO ontologyBLASTP
38721953872905711putative lipoprotein LPQDQuickGO ontologyBLASTP
387295138749031953putative multi-functional enzyme with acyl-CoA-reductase activity ACRA1QuickGO ontologyBLASTP
38749043875767864cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1QuickGO ontologyBLASTP
38757913876717927putative nucleoside hydrolase IUNHQuickGO ontologyBLASTP