Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_009565: Mycobacterium tuberculosis F11, complete genome

NCBI: NC_009565

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
147950050278923290Island text1.8298319.081328.2414Neighbours11BLASTN+479500.gbk
283307685178218707Island text1.7324515.916818.8939Neighbours11BLASTN+IslandViewer 833076.gbk
31098847*112029321447Island text1.6247119.471228.3051Neighbours11BLASTN+IslandViewer 1098847.gbk
41629780165615326374Island text1.4652118.14221.7932Neighbours11BLASTN+1629780.gbk
51688642171216323522Island text2.0628121.742923.9877Neighbours11BLASTN+IslandViewer 1688642.gbk
61866214189074224529Island text1.7296419.716534.9614Neighbours11BLASTN+1866214.gbk
72306574*233169725124Island text1.4411617.418528.9438Neighbours11BLASTN2306574.gbk
82806000282822922230Island text1.4631518.622322.8834Neighbours11BLASTN2806000.gbk
93128094314823720144Island text1.5339221.006833.6046Neighbours11BLASTN+IslandViewer 3128094.gbk
103299937332177021834Island text1.5327417.031531.2685Neighbours11BLASTN+3299937.gbk
113485772350477419003Island text1.5394116.814618.3031Neighbours11BLASTN+3485772.gbk
123793976381869024715Island text1.5475519.157326.0141Neighbours11BLASTN+IslandViewer 3793976.gbk