Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:3299937 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
329993733011781242transposaseQuickGO ontologyBLASTP
33012633301979717transposaseQuickGO ontologyBLASTP
33020973302798702lipoprotein lppXQuickGO ontologyBLASTP
330297633078264851polyketide synthase pks1QuickGO ontologyBLASTP
330782333093131491polyketide synthase pks15QuickGO ontologyBLASTP
330931033114272118fatty-acid-CoA ligase fadD22QuickGO ontologyBLASTP
33114443312043600hypothetical proteinBLASTP
331206933139281860fatty-acid-CoA ligase fadD29QuickGO ontologyBLASTP
331457633157211146hypothetical oxidoreductaseQuickGO ontologyBLASTP
33159143316726813hypothetical methyltransferaseQuickGO ontologyBLASTP
331675233180081257hypothetical proteinBLASTP
33181393318864726hypothetical proteinBLASTP
33190533320018966hypothetical proteinBLASTP
33201413320872732hypothetical proteinBLASTP
33209433321770828hypothetical glycosyl transferaseQuickGO ontologyBLASTP