Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:1688642 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
168864216908942253methylmalonyl-CoA mutase large subunit mutBQuickGO ontologyBLASTP
16909081691210303hypothetical proteinBLASTP
16912071691524318hypothetical proteinBLASTP
169152116925251005arginineornithine transport system ATPaseQuickGO ontologyBLASTP
169258116938671287esterase lipLQuickGO ontologyBLASTP
16939401694557618hypothetical methyltransferaseQuickGO ontologyBLASTP
16947711694983213hypothetical proteinBLASTP
16950441695442399hypothetical proteinBLASTP
169548716965151029hypothetical glycosyltransferaseQuickGO ontologyBLASTP
16965271697348822hypothetical proteinBLASTP
16975611698460900hypothetical proteinBLASTP
16986331699175543hypothetical proteinBLASTP
16991821699781600hypothetical proteinBLASTP
16999181700583666hypothetical proteinBLASTP
17005801701080501hypothetical proteinBLASTP
17013641702059696hypothetical proteinBLASTP
17019931702496504hypothetical proteinBLASTP
170273217045311800hypothetical membrane proteinQuickGO ontologyBLASTP
17045031704865363hypothetical proteinBLASTP
17048491705730882hypothetical proteinBLASTP
170593217072301299hypothetical proteinBLASTP
17072341707653420hypothetical proteinBLASTP
170771117087331023GDP-D-mannose dehydratase gmdAQuickGO ontologyBLASTP
17087301709698969nucleotide-sugar epimerase epiAQuickGO ontologyBLASTP
17096951710426732hypothetical proteinBLASTP
17104441711232789hypothetical proteinBLASTP
17112671712163897hypothetical proteinBLASTP