Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:1866214 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18653121866235924ornithine carbamoyltransferase argFQuickGO ontologyBLASTP
18662141866744531arginine repressor argRQuickGO ontologyBLASTP
186675318679491197argininosuccinate synthase argGQuickGO ontologyBLASTP
186802918694411413argininosuccinate lyase argHQuickGO ontologyBLASTP
186955018706111062chalcone synthase pks10QuickGO ontologyBLASTP
187069418770746381polyketide synthase pks7QuickGO ontologyBLASTP
187709418819024809polyketide synthase pks8QuickGO ontologyBLASTP
188190218834101509polyketide synthase pks17QuickGO ontologyBLASTP
188341618864693054polyketide synthase pks9QuickGO ontologyBLASTP
188661618876771062chalcone synthase pks11QuickGO ontologyBLASTP
188766018889521293cytochrome P450 139 cyp139QuickGO ontologyBLASTP
188896718907421776hypothetical macrolide-transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP