Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:1098847 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109884711002201374PE-PGRS family proteinQuickGO ontologyBLASTP
11005851101277693mycobacterial persistence regulator mprA two component response transcriptional regulatory proteinQuickGO ontologyBLASTP
110127711027911515two component system sensor kinase mprBQuickGO ontologyBLASTP
110283511042291395serine protease pepDQuickGO ontologyBLASTP
11042291104774546pterin-4-alpha-carbinolamine dehydratase moaB2QuickGO ontologyBLASTP
11047941105249456large-conductance ion mechanosensitive channel mscLQuickGO ontologyBLASTP
11056041106317714hypothetical adhesion component transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
110631011088772568hypothetical adhesion component transport transmembrane protein ABC transporterQuickGO ontologyBLASTP
110888411100441161hypothetical proteinBLASTP
11101731111150978polyprenyl-diphosphate synthase grcC2QuickGO ontologyBLASTP
11112111111867657hypothetical proteinBLASTP
11119401112272333conserved serine rich proteinQuickGO ontologyBLASTP
11123461112939594hypothetical proteinBLASTP
11130401113960921UTP-glucose-1-phosphate uridylyltransferase galUQuickGO ontologyBLASTP
111403711153171281molybdopterin biosynthesis protein moeA1QuickGO ontologyBLASTP
11153381115991654ribosomal protein alanine acetyltransferase rimJQuickGO ontologyBLASTP
111605311172281176conserved transmembrane proteinQuickGO ontologyBLASTP
11176291117880252hypothetical proteinBLASTP
11180611118492432hypothetical proteinBLASTP
111851611195171002hypothetical proteinBLASTP
11195351120293759hypothetical proteinBLASTP