Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:479500 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
479564479812249hypothetical proteinBLASTP
479849480490642hypothetical secreted proteinQuickGO ontologyBLASTP
4804974817261230lipoprotein lpqKQuickGO ontologyBLASTP
4817364829231188acyl-CoA dehydrogenase fadE7QuickGO ontologyBLASTP
482959483330372conserved transmembrane proteinQuickGO ontologyBLASTP
4835254864012877transmembrane transport protein mmpL1QuickGO ontologyBLASTP
486398486826429membrane protein mmpS1QuickGO ontologyBLASTP
4871474889041758fatty-acid-CoA ligase fadD30QuickGO ontologyBLASTP
4889014931094209membrane bound polyketide synthase pks6QuickGO ontologyBLASTP
493057493875819beta lactamase like proteinQuickGO ontologyBLASTP
4939534949631011F420-dependent glucose-6-phosphate dehydrogenase fgd1QuickGO ontologyBLASTP
4949564970282073phosphate acetyltransferase ptaQuickGO ontologyBLASTP
4970214981781158acetate kinase ackA acetokinaseQuickGO ontologyBLASTP
4982325004842253serinethreonine-protein kinase pknGQuickGO ontologyBLASTP
500484501470987glutamine-binding lipoprotein glnHQuickGO ontologyBLASTP
5014705027891320hypothetical proteinBLASTP