Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:3485772 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
348577234871421371NADPHadrenodoxin oxidoreductase fprAQuickGO ontologyBLASTP
348714334887261584alkyldihydroxyacetonephosphate synthase agpSQuickGO ontologyBLASTP
34888253489265441hypothetical proteinBLASTP
348941434904931080molybdenum cofactor biosynthesis protein A moaA1QuickGO ontologyBLASTP
34905443490939396pterin-4-alpha-carbinolamine dehydratase moaB1QuickGO ontologyBLASTP
34909363491448513molybdenum cofactor biosynthesis protein C moaC1QuickGO ontologyBLASTP
34914653491716252molybdenum cofactor biosynthesis protein D moaD1QuickGO ontologyBLASTP
34921903492516327transposaseQuickGO ontologyBLASTP
34925673493451885transposaseQuickGO ontologyBLASTP
34938823494412531hypothetical proteinBLASTP
349451134958211311transposaseQuickGO ontologyBLASTP
349589934970681170molybdenum cofactor biosynthesis protein moeB2QuickGO ontologyBLASTP
34970973497930834thiosulfate sulfurtransferase cysA3QuickGO ontologyBLASTP
34979323498234303hypothetical protein sseC1QuickGO ontologyBLASTP
34982553498698444molybdenum cofactor biosynthesis protein E moaE1QuickGO ontologyBLASTP
34986953499297603hypothetical proteinBLASTP
349963235008341203cytochrome P450 141 cyp141QuickGO ontologyBLASTP
35012123501682471hypothetical proteinBLASTP
35017073502186480hypothetical proteinBLASTP
35026053503498894hypothetical transcriptional regulatory proteinQuickGO ontologyBLASTP
350359935047741176PPE family proteinQuickGO ontologyBLASTP