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Query: NC_009565:3485772:3493882 Mycobacterium tuberculosis F11, complete genome

Start: 3493882, End: 3494412, Length: 531

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:3465582:347652334765233477086564Mycobacterium tuberculosis CDC1551, complete genomecytidine and deoxycytidylate deaminase family protein2e-99360
NC_017026:3466809:347480434748043475334531Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein4e-99360
NC_000962:3474000:348075934807593481289531Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-99360
NC_009525:3484924:349291534929153493445531Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-99360
NC_008769:3427254:343524534352453435775531Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-98357
NC_012207:3421144:342789534278953428425531Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-98357
NC_002945:3429315:343730634373063437836531Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-98357
NC_016804:3407859:341461034146103415140531Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-98357
NC_014221:398636:419338419338419799462Truepera radiovictrix DSM 17093 chromosome, complete genomeCMP/dCMP deaminase zinc-binding protein7e-1270.1
NC_014656:1704101:170629917062991706748450Bifidobacterium longum subsp. longum BBMN68 chromosome, completecumb9e-0959.7
NC_014169:2407266:242451924245192425043525Bifidobacterium longum subsp. longum JDM301 chromosome, completeCMP/dCMP deaminase1e-0859.7
NC_010723:575254:601521601521601994474Clostridium botulinum E3 str. Alaska E43, complete genomecytidine/deoxycytidylate deaminase family protein2e-0858.5
NC_014328:3294086:329867632986763299167492Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative purine deaminase, zinc-binding domain3e-0857.8
NC_010674:615963:636253636253636726474Clostridium botulinum B str. Eklund 17B, complete genomecytidine/deoxycytidylate deaminase family protein7e-0857
NC_009667:1341000:135869413586941359164471Ochrobactrum anthropi ATCC 49188 chromosome 1, complete sequenceCMP/dCMP deaminase zinc-binding1e-0756.2
NC_013665:918313:938640938640939104465Methanocella paludicola SANAE, complete genomeputative deaminase2e-0755.1
NC_013131:9903320:993957299395729940045474Catenulispora acidiphila DSM 44928, complete genomeCMP/dCMP deaminase zinc-binding2e-0755.1
NC_004193:375416:407939407939408418480Oceanobacillus iheyensis HTE831, complete genomehypothetical protein3e-0754.7
NC_013223:1848689:185639318563931856890498Desulfohalobium retbaense DSM 5692, complete genomeCMP/dCMP deaminase zinc-binding4e-0754.3
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome4e-0754.3
NC_003155:4441559:444964244496424450097456Streptomyces avermitilis MA-4680, complete genomehypothetical protein1e-0653.1
NC_013715:193647:201658201658202185528Rothia mucilaginosa DY-18, complete genomecytosine/adenosine deaminase1e-0652.8
NC_008314:36500:566895668957126438Ralstonia eutropha H16 chromosome 2, complete sequencePutative Cytosine/adenosine deaminase2e-0652
NC_014614:86213:899398993990403465Clostridium sticklandii, complete genomeguanine deaminase3e-0651.6
NC_014815:2639339:264051526405152641141627Micromonospora sp. L5 chromosome, complete genomecmp/dcmp deaminase zinc-binding protein3e-0651.2
NC_014391:6640327:665013066501306650762633Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeCMP/dCMP deaminase3e-0651.2
NC_020133:5965500:597153459715345971992459Mycobacterium liflandii 128FXT, complete genomecytidine/deoxycytidylate deaminase8e-0650.1
NC_010612:6385520:639627063962706396728459Mycobacterium marinum M, complete genomecytidine/deoxycytidylate deaminase8e-0650.1