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Query: NC_009565:1629780 Mycobacterium tuberculosis F11, complete genome

Start: 1629780, End: 1656153, Length: 26374

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_015848:16475231647523167029122769Mycobacterium canettii CIPT 140010059, complete genome016300BLASTN svgBLASTP svg
NC_002945:16217651621765164826226498Mycobacterium bovis AF2122/97, complete genome014390BLASTN svgBLASTP svg
NC_020133:2886541*2886541291380027260Mycobacterium liflandii 128FXT, complete genome02190BLASTN svgBLASTP svg
NC_012522:75960397596039763616240124Rhodococcus opacus B4, complete genome4e-144519BLASTN svgBLASTP svg
NC_018524:57484215748421577627827858Nocardiopsis alba ATCC BAA-2165 chromosome, complete genome8e-47196BLASTN svgBLASTP svg
NC_010612:95778695778698186224077Mycobacterium marinum M, complete genome3e-28135BLASTN svgBLASTP svg
NC_013521:2193203*2193203221998826786Sanguibacter keddieii DSM 10542, complete genome9e-19103BLASTN svgBLASTP svg
NC_020133:24219652421965244809926135Mycobacterium liflandii 128FXT, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_006834:14141131414113144373429622Xanthomonas oryzae pv. oryzae KACC10331, complete genome6e-1797.6BLASTN svgBLASTP svg
NC_007705:13886071388607141722428618Xanthomonas oryzae pv. oryzae MAFF 311018, complete genome6e-1797.6BLASTN svgBLASTP svg
NC_010717:39334853933485396259929115Xanthomonas oryzae pv. oryzae PXO99A, complete genome6e-1797.6BLASTN svgBLASTP svg
NC_015387:1898496*1898496191959921104Marinithermus hydrothermalis DSM 14884 chromosome, complete genome6e-1797.6BLASTN svgBLASTP svg
NC_020133:90200090200092552523526Mycobacterium liflandii 128FXT, complete genome9e-1693.7BLASTN svgBLASTP svg
NC_015690:11093351109335116959960265Paenibacillus mucilaginosus KNP414 chromosome, complete genome9e-1693.7BLASTN svgBLASTP svg
NC_015376:20100092010009204069430686Burkholderia gladioli BSR3 chromosome chromosome 2, complete3e-1591.7BLASTN svgBLASTP svg
NC_002935:1237585*1237585131159974015Corynebacterium diphtheriae NCTC 13129, complete genome8e-1383.8BLASTN svgBLASTP svg
NC_015848:28591452859145288297223828Mycobacterium canettii CIPT 140010059, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_019950:28306822830682285444023759Mycobacterium canettii CIPT 140060008 complete genome3e-1281.8BLASTN svgBLASTP svg
NC_013851:85939685939688482325428Allochromatium vinosum DSM 180 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_014329:11696741169674119345823785Corynebacterium pseudotuberculosis FRC41 chromosome, complete2e-1075.8BLASTN svgBLASTP svg
NC_009525:39335673933567395892925363Mycobacterium tuberculosis H37Ra, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_008752:10259801025980106353637557Acidovorax avenae subsp. citrulli AAC00-1, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_010612:54030005403000542141218413Mycobacterium marinum M, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_020133:50205005020500504274122242Mycobacterium liflandii 128FXT, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_010172:57304657304660029627251Methylobacterium extorquens PA1, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_002935:1315019*1315019137072155703Corynebacterium diphtheriae NCTC 13129, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_020133:14439341443934146609922166Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_020133:57106615710661573224421584Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_009439:49137674913767493609922333Pseudomonas mendocina ymp, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_009952:1680682*1680682171856437883Dinoroseobacter shibae DFL 12, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_015954:2764919*2764919280819843280Halophilic archaeon DL31 chromosome, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_000962:27910192791019281491123893Mycobacterium tuberculosis H37Rv, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_002755:27880002788000281039922400Mycobacterium tuberculosis CDC1551, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_002945:27578212757821278170823888Mycobacterium bovis AF2122/97, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_008769:27548282754828277870723880Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009439:44289044289048900846119Pseudomonas mendocina ymp, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009525:28029872802987282687923893Mycobacterium tuberculosis H37Ra, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009565:28060002806000282822922230Mycobacterium tuberculosis F11, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010612:61131556113155613265419500Mycobacterium marinum M, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012207:27475992747599277148023882Mycobacterium bovis BCG str. Tokyo 172, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_018681:56279405627940567856250623Nocardia brasiliensis ATCC 700358 chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009664:1569335*1569335161469045356Kineococcus radiotolerans SRS30216, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_012560:16273341627334164585618523Azotobacter vinelandii DJ, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_015387:10029551002955103001227058Marinithermus hydrothermalis DSM 14884 chromosome, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_021150:16273471627347165194824602Azotobacter vinelandii CA6, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_013855:1268424*1268424129242324000Azospirillum sp. B510 plasmid pAB510a, complete sequence3e-0661.9BLASTN svgBLASTP svg
NC_013205:2610956*2610956266117350218Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,3e-0661.9BLASTN svgBLASTP svg