Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:2806000 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
280603928073041266carboxylesterase lipQQuickGO ontologyBLASTP
28076662808436771enoyl-CoA hydratase echA14QuickGO ontologyBLASTP
28086172809378762PE-PGRS family proteinQuickGO ontology
280940728107021296PE-PGRS family proteinQuickGO ontologyBLASTP
281078428141973414hypothetical transcriptional regulatory protein luxR-familyQuickGO ontologyBLASTP
28141632814462300hypothetical alanine rich proteinQuickGO ontologyBLASTP
281457128188094239PE-PGRS family proteinQuickGO ontology
28187272819545819PE-PGRS family proteinQuickGO ontologyBLASTP
28199832820606624hypothetical proteinBLASTP
28205962821348753hypothetical proteinBLASTP
28216282822053426hypothetical proteinBLASTP
282207628232571182dihydrolipoamide S-acetyltransferase E2 component pdhCQuickGO ontologyBLASTP
282325428243001047pyruvate dehydrogenase E1 component beta subunit pdhBQuickGO ontologyBLASTP
282431128254141104pyruvate dehydrogenase E1 component alpha subunit pdhAQuickGO ontologyBLASTP
28256732826494822citrate lyase beta subunit citEQuickGO ontologyBLASTP
28264912827048558hypothetical oxidase regulatory-related proteinQuickGO ontologyBLASTP
282704528282291185acyl-CoA dehydrogenase fadE19QuickGO ontologyBLASTP