Pre_GI Gene

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Host: NC_009565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009565:3128094 Mycobacterium tuberculosis F11, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31280943128702609hypothetical proteinBLASTP
312877331301821410transposaseQuickGO ontologyBLASTP
31301793130991813hypothetical proteinBLASTP
31325213133405885transposaseQuickGO ontologyBLASTP
31334563133782327transposaseQuickGO ontologyBLASTP
31352543135595342hypothetical proteinBLASTP
313559631366121017hypothetical proteinBLASTP
313662531378721248hypothetical proteinBLASTP
313786931389961128hypothetical proteinBLASTP
31389933139901909hypothetical proteinBLASTP
31398823140592711hypothetical proteinBLASTP
31406023140976375hypothetical proteinBLASTP
314097331434112439hypothetical proteinBLASTP
31434083144352945hypothetical proteinBLASTP
31445303145270741hypothetical proteinBLASTP
31453473146237891hypothetical proteinBLASTP
31462343147121888hypothetical proteinBLASTP
31474263147971546hypothetical proteinBLASTP
31479683148237270hypothetical proteinBLASTP