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Query: NC_012563:2680246:2686417 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2686417, End: 2687442, Length: 1026

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2531750:2558608255860825596331026Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-170597
NC_009699:2552195:2558468255846825594931026Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-170597
NC_012563:1681639:1696913169691316979621050Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-79295
NC_012658:1405788:1408652140865214097011050Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-78293
NC_017297:3428429:3452369345236934534181050Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-77290
NC_009699:3429817:3453755345375534548041050Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-77290
NC_020291:5808856:5830296583029658313331038Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-77289
NC_010516:2676746:2701931270193127029801050Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-77289
NC_009697:2558286:2583575258357525846241050Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein9e-76283
NC_010418:188138:2012522012522022771026Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completehypothetical protein6e-72271
NC_016012:1312352:1329789132978913308231035Candidatus Arthromitus sp. SFB-rat-Yit, complete genomehypothetical protein3e-41169
NC_015913:1422444:1439899143989914409211023Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein6e-40164
NC_017294:1385576:1406295140629514073321038Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomehypothetical protein7e-40164
NC_016627:3659500:3660568366056836615931026Clostridium clariflavum DSM 19732 chromosome, complete genomenucleoid-associated protein2e-39162
NC_017179:1133510:1144977114497711459811005Clostridium difficile BI1, complete genomehypothetical protein1e-36154
NC_013315:1123733:1135200113520011362041005Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-36154
NC_009089:1093832:110417811041781105173996Clostridium difficile 630, complete genomephage protein1e-32140
NC_014828:1795781:180536718053671806356990Ethanoligenens harbinense YUAN-3 chromosome, complete genomehypothetical protein3e-1272.8