Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3428429 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34284293429166738hypothetical proteinBLASTP
34293193430221903putative N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
34303613430777417toxin secretionphage lysis holinQuickGO ontologyBLASTP
34308743430996123hypothetical proteinBLASTP
34309893431384396hypothetical proteinBLASTP
343139834330621665putative phage structural proteinQuickGO ontologyBLASTP
34330693433992924hypothetical proteinBLASTP
34341403435009870putative phage tail proteinQuickGO ontologyBLASTP
34405613440689129hypothetical proteinBLASTP
34407763441063288hypothetical proteinBLASTP
34410993441680582phage major tail protein phi13 familyQuickGO ontologyBLASTP
34416803442027348hypothetical proteinBLASTP
34420243442407384phage protein HK97 gp10 familyQuickGO ontologyBLASTP
34424003442726327putative phage head-tail adaptorQuickGO ontologyBLASTP
34427073443036330phage protein QLRG familyQuickGO ontologyBLASTP
34430533443208156hypothetical proteinBLASTP
344322834443551128putative phage capsid proteinQuickGO ontologyBLASTP
34443483445148801putative Clp proteaseQuickGO ontologyBLASTP
34451843445297114phage portal protein HK97 familyQuickGO ontologyBLASTP
344535034463781029phage portal protein HK97 familyQuickGO ontologyBLASTP
344639434480911698putative phage terminase large subunitQuickGO ontologyBLASTP
34480883448561474phage terminase small subunitQuickGO ontologyBLASTP
34488193449217399hypothetical proteinBLASTP
34492923449585294hypothetical proteinBLASTP
34496193449960342hypothetical proteinBLASTP
34499983450273276hypothetical proteinBLASTP
34504273450972546site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
34509743451207234hypothetical proteinBLASTP
34514163451799384hypothetical proteinBLASTP
34517923451959168hypothetical proteinBLASTP
34519623452105144hypothetical proteinBLASTP
34521203452278159hypothetical proteinBLASTP
345236934534181050hypothetical proteinBLASTP
34534573453603147hypothetical proteinBLASTP
34536373453807171hypothetical proteinBLASTP
34538403454025186hypothetical proteinBLASTP
34540633454335273hypothetical proteinBLASTP
34543693454590222hypothetical proteinBLASTP