Pre_GI Gene

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Host: NC_010418 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010418:188138 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
188138188644507hypothetical proteinBLASTP
188826189278453hypothetical proteinBLASTP
189323189670348hypothetical protein
189711189863153hypothetical protein
189982190650669serinethreonine protein phosphataseQuickGO ontologyBLASTP
190702190884183hypothetical protein
191282191785504hypothetical proteinBLASTP
192061192570510hypothetical proteinBLASTP
192979193287309hypothetical proteinBLASTP
193355193678324hypothetical proteinBLASTP
193703193933231hypothetical proteinBLASTP
193994194215222hypothetical proteinBLASTP
194246194797552hypothetical proteinBLASTP
194794195498705Upf868QuickGO ontologyBLASTP
195560195922363hypothetical protein
195958196443486hypothetical protein
196482196814333hypothetical proteinBLASTP
196880197140261hypothetical proteinBLASTP
197196197540345hypothetical proteinBLASTP
197738197944207hypothetical protein
1983021993901089amidase domain proteinQuickGO ontologyBLASTP
199471199794324hypothetical protein
199916200620705hypothetical protein
200774201067294hypothetical protein
2012522022771026hypothetical proteinBLASTP
202382202708327hypothetical protein
202837203226390hypothetical protein
203279203584306hypothetical protein
203651203836186hypothetical protein
203907204086180hypothetical protein
204136204354219hypothetical protein
204462204998537conserved phage proteinQuickGO ontologyBLASTP
205061205522462hypothetical proteinBLASTP
205627206418792hypothetical proteinBLASTP
206518206973456hypothetical protein
2073572087991443putative IS transposaseQuickGO ontologyBLASTP