Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2531750 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25317502532505756hypothetical protein
25326672532849183hypothetical proteinBLASTP
25328512533192342hypothetical proteinBLASTP
253320425343851182tail fiber protein HQuickGO ontologyBLASTP
25345432535016474hypothetical proteinBLASTP
25358652536092228BLASTP
25360932536500408hypothetical proteinBLASTP
25365032536814312hypothetical proteinBLASTP
25368512537825975hypothetical proteinBLASTP
25378412538518678lysM domain proteinQuickGO ontologyBLASTP
253851825406772160putative tail length tape measure proteinQuickGO ontologyBLASTP
25407352541496762hypothetical proteinBLASTP
25417332542146414hypothetical proteinBLASTP
25421642542628465core tail proteinQuickGO ontologyBLASTP
254263225439421311hypothetical proteinBLASTP
25439442544114171hypothetical proteinBLASTP
25441042544493390hypothetical proteinBLASTP
25445442544708165hypothetical protein
25447222545213492hypothetical proteinBLASTP
25452132545596384hypothetical proteinBLASTP
25455982545942345hypothetical proteinBLASTP
25459562546921966phage coat proteinQuickGO ontologyBLASTP
25469412547546606phage minor structural protein GP20QuickGO ontologyBLASTP
25475672547830264hypothetical proteinBLASTP
25478472548215369hypothetical proteinBLASTP
25482462548440195hypothetical protein
254845725494791023phage head morphogenesis proteinQuickGO ontologyBLASTP
254946925509201452phage portal protein SPP1 familyQuickGO ontologyBLASTP
255093325523421410hypothetical proteinBLASTP
25523352552922588putative phage terminase small subunitQuickGO ontologyBLASTP
25531452553696552hypothetical proteinBLASTP
25536832554060378hypothetical proteinBLASTP
255406925554331365SNF2 domain proteinQuickGO ontologyBLASTP
25554362555603168hypothetical proteinBLASTP
25555962555784189VRR-NUC domain-containing proteinQuickGO ontologyBLASTP
255613825585612424putative virulence-associated protein EQuickGO ontologyBLASTP
255860825596331026hypothetical proteinBLASTP
25596762559960285hypothetical proteinBLASTP
25599992560229231hypothetical proteinBLASTP
256027825617081431C-5 cytosine-specific DNA methylaseQuickGO ontologyBLASTP
256263125637251095BLASTP
25637462563925180hypothetical proteinBLASTP
25639562564126171hypothetical proteinBLASTP
25645182564829312BLASTP
256484125659861146hypothetical proteinBLASTP
25659862566150165hypothetical proteinBLASTP
25661502566596447hypothetical proteinBLASTP
25666422566896255hypothetical proteinBLASTP
25668962567147252hypothetical proteinBLASTP
25672112567762552sigma-70 family RNA polymerase sigma factorQuickGO ontologyBLASTP
25679672568125159hypothetical proteinBLASTP
25681222568973852hypothetical proteinBLASTP
25690352569178144hypothetical proteinBLASTP
25692732569470198DNA-binding proteinQuickGO ontologyBLASTP
25697622570139378DNA-binding proteinQuickGO ontologyBLASTP
257015125713741224BLASTP