Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:1405788 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14057881406594807DNA methylaseQuickGO ontologyBLASTP
14066621406925264hypothetical proteinBLASTP
14069691407118150putative mszf55-1QuickGO ontology
14071531407305153hypothetical protein
14073611408176816hypothetical proteinBLASTP
14082141408408195hypothetical proteinBLASTP
14084221408625204hypothetical proteinBLASTP
140865214097011050hypothetical proteinBLASTP
14098081410512705hypothetical proteinBLASTP
14105631410706144hypothetical proteinBLASTP
14107091410870162hypothetical proteinBLASTP
14108671411256390hypothetical proteinBLASTP
14114791411694216hypothetical proteinBLASTP
14116961412241546phage integrase family site-specific recombinaseQuickGO ontologyBLASTP
14123891412694306Gp54 proteinQuickGO ontologyBLASTP
14128591413359501terminase small subunitQuickGO ontologyBLASTP
141334614149771632putative phage terminase large subunitQuickGO ontologyBLASTP
141503414161521119phage portal protein HK97 familyQuickGO ontologyBLASTP
14161271416780654prohead proteaseQuickGO ontologyBLASTP
141678414179351152mAjor capsid protein aQuickGO ontologyBLASTP
14179351418216282Gp6 proteinQuickGO ontologyBLASTP
14182101418569360putative phage head-tail adaptorQuickGO ontology
14185891418999411XkdN proteinQuickGO ontologyBLASTP
14192471419504258hypothetical protein
14195501419960411hypothetical protein
14199571420388432hypothetical protein
142039414214551062hypothetical proteinBLASTP
14214581421886429putative phage protein XkdMQuickGO ontologyBLASTP
142195814244982541phage proteinQuickGO ontologyBLASTP