Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016511: Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

NCBI: NC_016511

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1151003833123232Island text1.6235926.69632.5298Neighbours11BLASTN+15100.gbk
223443126067026240Island text1.7401426.168845.4224Neighbours11BLASTN+234431.gbk
330824432609917856Island text1.6937323.312940.0353Neighbours11BLASTN308244.gbk
4472666*49623323568Island text1.4408125.30441.1743Neighbours11BLASTN+472666.gbk
567858270230223721Island text2.7631728.689952.4979Neighbours11BLASTN+678582.gbk
6844500*87541330914Island text1.5859924.176243.7142Neighbours56BLASTN+844500.gbk
71212282123311220831Island text1.9582928.698947.705Neighbours11BLASTN1212282.gbk
81354949*137844423496Island text1.8007623.987739.8039BLASTN+1354949.gbk
91811171183431423144Island text2.775234.896841.9012Neighbours11BLASTN+1811171.gbk
102321999*234895326955Island text1.9319427.877846.0538Neighbours11BLASTN+2321999.gbk
112389273241202122749Island text1.952529.392243.4697Neighbours11BLASTN+2389273.gbk
122482500*250949927000Island text1.7031724.860242.4223Neighbours11BLASTN2482500.gbk