Pre_GI Gene

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Host: NC_016511 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016511:1212282 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
121228212143212040beta-lactamaseQuickGO ontologyBLASTP
12144201215067648hypothetical proteinBLASTP
12150771215949873transcriptional regulatorQuickGO ontologyBLASTP
12160751216989915N-acetylmuramic acid 6-phosphate etheraseQuickGO ontologyBLASTP
121700912185261518phosphotransferase system EIICQuickGO ontologyBLASTP
12185301218976447hypothetical proteinBLASTP
12189661219901936BadFBadGBcrABcrD ATPase family proteinQuickGO ontologyBLASTP
121989812209081011Tat twin-arginine translocation pathway signal sequenceQuickGO ontologyBLASTP
122090512223351431glycosyl hydrolase family proteinQuickGO ontologyBLASTP
12223631222674312PTS system LactoseCellobiose specific IIB subunitQuickGO ontologyBLASTP
122267112239481278putative PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
12239451224310366PTS system LactoseCellobiose specific IIA subunitQuickGO ontologyBLASTP
122527512288473573DNA polymerase III subunit alphaQuickGO ontologyBLASTP
12288441229398555hypothetical proteinBLASTP
122942112307221302bifunctional histidinal dehydrogenase histidinol dehydrogenaseQuickGO ontologyBLASTP
123071912318851167histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
12318821232502621imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
12324951233112618imidazole glycerol phosphate synthase glutamine amidotransferase subunitQuickGO ontologyBLASTP