Pre_GI Gene

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Host: NC_016511 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016511:15100 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1510016068969L-lactate dehydrogenaseQuickGO ontologyBLASTP
16586175931008transcriptional regulatorQuickGO ontologyBLASTP
17590190951506ABC transporterQuickGO ontologyBLASTP
1931920155837ribose ABC transport system permease protein RbsCribose ABC transport system periplasmic ribose-binding protein RbsBQuickGO ontologyBLASTP
2020421145942periplasmic sugar-binding proteinQuickGO ontologyBLASTP
2114222071930sugar kinaseQuickGO ontologyBLASTP
2206822451384D-ribose pyranaseQuickGO ontologyBLASTP
2270022903204hypothetical proteinBLASTP
2305523531477PTS system galactitol-specific transporter subunit IIAQuickGO ontologyBLASTP
23588248441257PTS system galactitol-specific transporter subunit IICQuickGO ontologyBLASTP
2486525167303PTS system galactitol-specific transporter subunit IIBQuickGO ontologyBLASTP
2515725540384alcohol dehydrogenaseQuickGO ontologyBLASTP
2581526156342HTH domain proteinQuickGO ontologyBLASTP
26291277061416HTH domain proteinQuickGO ontologyBLASTP
2863228847216hypothetical proteinBLASTP
2927529478204hypothetical proteinBLASTP
2984930493645phosphataseQuickGO ontologyBLASTP
3061031368759DeoR family transcriptional regulatorQuickGO ontologyBLASTP
3198732724738hypothetical proteinBLASTP
33391344491059putative aminotransferaseQuickGO ontologyBLASTP
3445335283831phospholipaseQuickGO ontologyBLASTP
3538335949567acetyltransferaseQuickGO ontologyBLASTP
3596336622660hypothetical proteinBLASTP
3704037513474hypothetical proteinBLASTP
3751338331819hypothetical proteinBLASTP