Pre_GI Gene

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Host: NC_016511 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016511:1811171 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18111711812010840bifunctional biotin--acetyl-CoA-carboxylase synthetasebiotin operon repressorQuickGO ontologyBLASTP
18121421812513372hypothetical proteinBLASTP
181260618141801575propionyl-CoA carboxylase subunit betaQuickGO ontologyBLASTP
18141771814407231hypothetical proteinBLASTP
18144091815050642Maf-like proteinQuickGO ontologyBLASTP
18156251816044420hypothetical proteinBLASTP
18163011816975675short chain dehydrogenaseQuickGO ontologyBLASTP
18170791817882804bifunctional hydroxy-methylpyrimidine kinase hydroxy-phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
18180021818862861hypothetical proteinBLASTP
18188411819311471dicarboxylate carrier MatC domain proteinQuickGO ontologyBLASTP
182004318214131371hypothetical proteinBLASTP
18216081822606999magnesium transport proteinQuickGO ontologyBLASTP
18226031823034432NUDIX family hydrolaseQuickGO ontologyBLASTP
182337018251391770phosphoribosylglycinamide synthetaseQuickGO ontologyBLASTP
18251661825918753hypothetical proteinBLASTP
182595718273361380flavoprotein disulfide reductaseQuickGO ontologyBLASTP
18275251828337813putative purine nucleotide phosphorylaseQuickGO ontologyBLASTP
182836418300401677phosphoglucomutasephosphomannomutase alphabetaalpha domain IIQuickGO ontologyBLASTP
183007218317451674AMP-binding proteinQuickGO ontologyBLASTP
18319311832581651uridine kinaseQuickGO ontologyBLASTP
183266218343141653transporter major facilitator family proteinQuickGO ontologyBLASTP