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Query: NC_008262:654000:673573 Clostridium perfringens SM101, complete genome

Start: 673573, End: 675693, Length: 2121

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:676000:6953866953866975062121Clostridium perfringens ATCC 13124, complete genomeputative helicase01295
NC_003366:728859:7480767480767501962121Clostridium perfringens str. 13, complete genomehypothetical protein01292
NC_004557:2607073:2609418260941826115502133Clostridium tetani E88, complete genomeATP-dependent DNA helicase rep0689
NC_016012:104500:1170321170321191252094Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeATP-dependent DNA helicase5e-110399
NC_011898:3973627:3977028397702839793102283Clostridium cellulolyticum H10, complete genomesuperfamily I DNA helicase1e-88328
NC_020291:4357425:4359233435923343614732241Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehelicase IV3e-82306
NC_012491:1187864:1187864118786411902242361Brevibacillus brevis NBRC 100599, complete genomeprobable DNA helicase involved in recombination1e-79298
NC_015978:352478:3729943729943752942301Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein2e-48194
NC_008593:841291:8579148579148601992286Clostridium novyi NT, complete genomesuperfamily I DNA helicase2e-46187
NC_017200:1157835:1176271117627111786042334Bacillus thuringiensis serovar finitimus YBT-020 chromosome,helicase, UvrD/Rep family protein6e-46186
NC_011772:1011220:1023748102374810260842337Bacillus cereus G9842, complete genomehelicase, UvrD/Rep family1e-45185
NC_015275:3407358:3444146344414634464312286Clostridium lentocellum DSM 5427 chromosome, complete genomeUvrD/REP helicase1e-45185
NC_011969:1084000:1101280110128011036162337Bacillus cereus Q1 chromosome, complete genomeATP-dependent DNA helicase replicase1e-45184
NC_011725:1032500:1048278104827810506112334Bacillus cereus B4264 chromosome, complete genomeUvrD/Rep family helicase2e-45184
NC_015975:441580:4644374644374667162280Lactobacillus ruminis ATCC 27782 chromosome, complete genomeATP-dependent DNA helicase5e-45183
NC_004722:1008500:1021931102193110242642334Bacillus cereus ATCC 14579, complete genomeATP-dependent DNA helicase rep5e-45183
NC_011773:1050000:1069750106975010720802331Bacillus cereus AH820 chromosome, complete genomeUvrD/Rep family helicase4e-45183
NC_003909:1139556:1140312114031211418891578Bacillus cereus ATCC 10987, complete genome3e-45183
NC_004567:343500:3840383840383863472310Lactobacillus plantarum WCFS1, complete genomeDNA helicase (putative)6e-45182
NC_013406:4023367:4037035403703540394612427Paenibacillus sp. Y412MC10 chromosome, complete genomeUvrD/Rep family helicase8e-45182
NC_014171:1018338:1036689103668910390222334Bacillus thuringiensis BMB171 chromosome, complete genomeATP-dependent DNA helicase rep8e-45182
NC_014334:1848340:1869908186990818721992292Lactobacillus casei str. Zhang chromosome, complete genomesuperfamily I DNA and RNA helicase1e-44181
NC_013199:1966334:1984402198440219866932292Lactobacillus rhamnosus Lc 705, complete genomesuperfamily I DNA and RNA helicase-like protein1e-44181
NC_016779:991298:1009000100900010113302331Bacillus cereus F837/76 chromosome, complete genomeUvrD/Rep family helicase1e-44181
NC_017208:1050414:1066257106625710685932337Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeATP-dependent DNA helicase rep1e-44181
NC_010184:1017000:1031326103132610336622337Bacillus weihenstephanensis KBAB4, complete genomeUvrD/REP helicase3e-44180
NC_015977:3424178:3522058352205835252703213Roseburia hominis A2-183 chromosome, complete genomeUvrD/Rep helicase family protein2e-42174
NC_009342:1570000:1585112158511215874632352Corynebacterium glutamicum R chromosome, complete genomehypothetical protein2e-31137
NC_004369:1552847:1568036156803615703812346Corynebacterium efficiens YS-314, complete genomehypothetical protein4e-29130
NC_013947:1296877:1296877129687712988141938Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeSuperfamily I DNA and RNA helicase-like protein6e-29129
NC_006361:4574536:4576673457667345788532181Nocardia farcinica IFM 10152, complete genomeputative helicase5e-28126
NC_016582:7946000:7960285796028579624622178Streptomyces bingchenggensis BCW-1 chromosome, complete genomesuperfamily I DNA and RNA helicase-like protein6e-27122
NC_012803:1552122:1568191156819115704672277Micrococcus luteus NCTC 2665, complete genomeDNA/RNA helicase, superfamily I7e-27122
NC_016582:10287865:1030133210301332103034102079Streptomyces bingchenggensis BCW-1 chromosome, complete genomesuperfamily I DNA and RNA helicase-like protein9e-27122
NC_016113:11500:1173611736137632028Streptomyces cattleya NRRL 8057 plasmid pSCAT, complete sequenceATP-dependent DNA helicase1e-26122
NC_018524:4988810:5009665500966550118152151Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeuvrD/REP helicase N-terminal domain protein4e-24113
NC_003909:1139556:113955611395561140365810Bacillus cereus ATCC 10987, complete genomehypothetical protein2e-22107
NC_013729:380312:3803123803123824802169Kribbella flavida DSM 17836, complete genomeSuperfamily I DNA and RNA helicase-like protein7e-22106
NC_013757:1888850:1891505189150518936552151Geodermatophilus obscurus DSM 43160, complete genomesuperfamily I DNA and RNA helicase1e-20102
NC_014210:3170537:3190003319000331931493147Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,Superfamily I DNA and RNA helicase4e-1997.1
NC_009973:301391:3101723101723123402169Herpetosiphon aurantiacus ATCC 23779 plasmid pHAU01, completesuperfamily I DNA/RNA helicase2e-1688.6
NC_013510:2937530:2960722296072229633072586Thermomonospora curvata DSM 43183, complete genomeSuperfamily I DNA and RNA helicase-like protein2e-1068.2
NC_017093:7234589:7240800724080072424881689Actinoplanes missouriensis 431, complete genomehypothetical protein1e-0965.9
NC_012918:1814000:1826660182666018285491890Geobacter sp. M21 chromosome, complete genomesuperfamily I DNA and RNA helicase-like protein2e-0965.5
NC_018867:10238:5577655776576231848Dehalobacter sp. CF chromosome, complete genomeATP-dependent DNA helicase UvrD/PcrA6e-0860.1
NC_007498:3399478:3401690340169034036661977Pelobacter carbinolicus DSM 2380, complete genomehypothetical protein6e-0860.1
NC_012034:6469:3152031520339792460Anaerocellum thermophilum DSM 6725, complete genomeLexA repressor7e-0756.6
NC_014720:4170:2587325873283322460Caldicellulosiruptor kronotskyensis 2002 chromosome, completelexa repressor1e-0655.5
NC_012704:1747539:1749208174920817513252118Corynebacterium kroppenstedtii DSM 44385, complete genomeputative ATP-dependent DNA helicase II4e-0653.9