Pre_GI Gene

Some Help

Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:728859 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
728859729182324hypothetical proteinBLASTP
7293637304631101probable permeaseQuickGO ontologyBLASTP
730721731380660probable pyrazinamidasenicotinamidaseQuickGO ontologyBLASTP
7317577330701314hypothetical proteinBLASTP
733374734297924glutaminaseQuickGO ontologyBLASTP
734586735311726probable Mg2 transport proteinQuickGO ontologyBLASTP
741120741812693sugar fermentation stimulation proteinQuickGO ontologyBLASTP
742291742764474hypothetical proteinBLASTP
7430707444701401diaminopimelate decarboxylaseQuickGO ontologyBLASTP
744879745145267hypothetical proteinBLASTP
745148745678531probable signal peptidase type IQuickGO ontologyBLASTP
7457037478562154cell division proteinQuickGO ontologyBLASTP
7480767501962121hypothetical proteinBLASTP
750652751488837probable amino acid ABC transporterQuickGO ontologyBLASTP
751519752190672probable amino acid ABC transporterQuickGO ontologyBLASTP
752187752909723probable amino acid ABC transporterQuickGO ontologyBLASTP
7531277549351809hypothetical proteinBLASTP