Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2607073 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
260707326082571185cobalt-zinc-cadmium resistance protein czcDQuickGO ontologyBLASTP
260830926093971089hypothetical proteinBLASTP
260941826115502133ATP-dependent DNA helicase repQuickGO ontologyBLASTP
261158826134621875cell division protein ftsHQuickGO ontologyBLASTP
261363726151181482glycerol kinaseQuickGO ontologyBLASTP
261539726165721176NAD-dependent malic enzymeQuickGO ontologyBLASTP
261668926178641176amidohydrolaseQuickGO ontologyBLASTP
261788426192811398transporterQuickGO ontologyBLASTP
261939526209481554citrate lyase alpha chainQuickGO ontologyBLASTP
26209382621870933citrate lyase beta chainQuickGO ontologyBLASTP
26224412623106666transcriptional regulator gntR familyQuickGO ontologyBLASTP
26234262623866441heat shock protein molecular chaperoneQuickGO ontologyBLASTP
26238972624592696hypothetical proteinBLASTP
26246382625231594putative transcription regulatorQuickGO ontologyBLASTP
26253842625977594molybdopterin-guanine dinucleotide biosynthesis protein AQuickGO ontologyBLASTP
26260162626699684hypothetical protein
26267172627193477carbon monoxide dehydrogenase small subunitQuickGO ontologyBLASTP
26271862628091906putative carbon-monoxide dehydrogenase middle subunitQuickGO ontologyBLASTP
262802126303842364putative carbon-monoxide dehydrogenase large subunitQuickGO ontologyBLASTP