Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:676000 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
676225676677453hypothetical proteinBLASTP
6767286778281101hypothetical proteinBLASTP
678125678745621isochorismatase family proteinQuickGO ontologyBLASTP
6791236804361314voltage-gated chloride channel family proteinQuickGO ontologyBLASTP
680740681663924glutaminaseQuickGO ontologyBLASTP
681964682686723MgtC family proteinQuickGO ontologyBLASTP
683146684663151816S ribosomal RNAQuickGO ontologyBLASTP
684849687753290523S ribosomal RNAQuickGO ontologyBLASTP
6878066879231185S ribosomal RNAQuickGO ontologyBLASTP
68793068800475tRNA-GluQuickGO ontology
688429689121693sugar fermentation stimulation proteinQuickGO ontologyBLASTP
689535690074540hydrolase NUDIX familyQuickGO ontologyBLASTP
6904856917801296diaminopimelate decarboxylaseQuickGO ontologyBLASTP
692189692455267hypothetical proteinBLASTP
692458692988531signal peptidase IQuickGO ontologyBLASTP
6930136951662154ATP-dependent metalloprotease FtsHQuickGO ontologyBLASTP
6953866975062121putative helicaseQuickGO ontologyBLASTP
697962698798837amino acid ABC transporter amino acid-binding proteinQuickGO ontologyBLASTP
698829699500672amino acid ABC transporter permease protein HisGluGlnArgopine familyQuickGO ontologyBLASTP
699497700219723amino acid ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
7004377022451809sulfatase family proteinQuickGO ontologyBLASTP