Pre_GI: BLASTP Hits

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Query: NC_008261:676000:687806 Clostridium perfringens ATCC 13124, complete genome

Start: 687806, End: 687923, Length: 118

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:225425:236090236090236207118Clostridium perfringens ATCC 13124, complete genome5S ribosomal RNA3e-1477
NC_008261:64678:870388703887155118Clostridium perfringens ATCC 13124, complete genome5S ribosomal RNA3e-1477
NC_008261:3014373:302924230292423029359118Clostridium perfringens ATCC 13124, complete genome5S ribosomal RNA3e-1477
NC_008261:304000:315356315356315473118Clostridium perfringens ATCC 13124, complete genome5S ribosomal RNA3e-1477
NC_008261:64678:772077720777324118Clostridium perfringens ATCC 13124, complete genome5S ribosomal RNA3e-1477
NC_003366:2556457:257444625744462574559114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:255480:266680266680266793114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:332500:344003344003344116114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:728859:740497740497740610114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:64908:110728110728110841114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:2788268:280661928066192806732114Clostridium perfringens str. 13, complete genome4e-1373.6
NC_003366:64908:100909100909101022114Clostridium perfringens str. 13, complete genome4e-1373.6