Pre_GI: BLASTP Hits

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Query: NC_008261:676000:678125 Clostridium perfringens ATCC 13124, complete genome

Start: 678125, End: 678745, Length: 621

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:728859:730721730721731380660Clostridium perfringens str. 13, complete genomeprobable pyrazinamidase/nicotinamidase2e-104377
NC_008262:654000:656116656116656736621Clostridium perfringens SM101, complete genomeisochorismatase family protein8e-102369
NC_016627:1133759:114945611494561150130675Clostridium clariflavum DSM 19732 chromosome, complete genomenicotinamidase-like amidase3e-41167
NC_015169:1:226252262523308684Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequenceisochorismatase hydrolase1e-22106
NC_017294:71494:749917499175584594Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeisochorismatase family protein5e-21100
NC_013939:1417750:142337214233721423887516Deferribacter desulfuricans SSM1, complete genomeisochorismatase hydrolase7e-1063.9
NC_016885:809000:814982814982815587606Pyrobaculum oguniense TE7 chromosome, complete genomeAmidases related to nicotinamidase2e-0962.8
NC_008701:391216:400802400802401407606Pyrobaculum islandicum DSM 4184, complete genomeisochorismatase hydrolase1e-0962.8
NC_011961:528837:538092538092538706615Thermomicrobium roseum DSM 5159 plasmid unnamed, complete sequenceisochorismatase hydrolase8e-0857
NC_011830:2177187:220011722001172200641525Desulfitobacterium hafniense DCB-2, complete genomeisochorismatase hydrolase3e-0755.1
NC_015320:743983:743983743983744516534Archaeoglobus veneficus SNP6 chromosome, complete genomeisochorismatase hydrolase9e-0753.5
NC_013504:1388480:140523214052321405777546Lactobacillus johnsonii FI9785 chromosome, complete genomehypothetical protein2e-0652.8