Pre_GI: BLASTP Hits

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Query: NC_007530:4251773:4271156 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 4271156, End: 4271908, Length: 753

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4252000:427105642710564271808753Bacillus anthracis str. A0248, complete genomeuroporphyrinogen-III synthase2e-136484
NC_003997:4252000:427102942710294271781753Bacillus anthracis str. Ames, complete genomeuroporphyrinogen-III synthetase2e-136484
NC_005945:4251789:427152842715284272280753Bacillus anthracis str. Sterne, complete genomeuroporphyrinogen-III synthetase2e-136484
NC_011773:4296082:430872943087294309481753Bacillus cereus AH820 chromosome, complete genomeuroporphyrinogen-III synthase3e-135480
NC_016779:4217171:422861042286104229362753Bacillus cereus F837/76 chromosome, complete genomeuroporphyrinogen-III synthase6e-133473
NC_008600:4263505:427736342773634278115753Bacillus thuringiensis str. Al Hakam, complete genomeuroporphyrinogen-III synthase6e-133473
NC_012472:4255729:427576442757644276516753Bacillus cereus 03BB102, complete genomeuroporphyrinogen-III synthase4e-132470
NC_005957:4244019:426061142606114261363753Bacillus thuringiensis serovar konkukian str. 97-27, completeuroporphyrinogen-III synthetase3e-127454
NC_006274:4295730:431547343154734316225753Bacillus cereus E33L, complete genomeuroporphyrinogen-III synthetase7e-127452
NC_003909:4209385:422429442242944225046753Bacillus cereus ATCC 10987, complete genomeuroporphyrinogen-III synthetase7e-127452
NC_016771:4195888:421617042161704216922753Bacillus cereus NC7401, complete genomeuroporphyrinogen-III synthase2e-126451
NC_011969:4140000:415893941589394159691753Bacillus cereus Q1 chromosome, complete genomeuroporphyrinogen-iii synthase2e-126451
NC_004722:4405363:441692644169264417678753Bacillus cereus ATCC 14579, complete genomeuroporphyrinogen-III synthetase4e-125447
NC_014171:4317520:433183743318374332589753Bacillus thuringiensis BMB171 chromosome, complete genomeuroporphyrinogen-III synthase4e-125447
NC_017200:4267408:428399542839954284747753Bacillus thuringiensis serovar finitimus YBT-020 chromosome,uroporphyrinogen-III synthase4e-125447
NC_011772:4397599:440924044092404409992753Bacillus cereus G9842, complete genomeuroporphyrinogen-III synthase3e-125447
NC_011725:4428726:444159244415924442344753Bacillus cereus B4264 chromosome, complete genomeuroporphyrinogen-III synthase8e-125446
NC_014335:4181710:420174542017454202497753Bacillus cereus biovar anthracis str. CI chromosome, completeuroporphyrinogen-III synthetase1e-123442
NC_017208:4435573:444650444465044447256753Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeuroporphyrinogen-III synthase2e-121435
NC_010184:4287999:430707043070704307822753Bacillus weihenstephanensis KBAB4, complete genomeUroporphyrinogen III synthase HEM42e-121435
NC_014829:3305762:332442433244243325197774Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeUroporphyrinogen III synthase HEM42e-29129
NC_016629:1111619:1114126111412611156491524Desulfovibrio africanus str. Walvis Bay chromosome, completeuroporphyrin-III C-methyltransferase8e-26117
NC_015589:1630461:1650285165028516518351551Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeuroporphyrin-III C-methyltransferase3e-25115
NC_017068:2436960:2497073249707324985811509Selenomonas ruminantium subsp. lactilytica TAM6421, completeuroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase1e-24113
NC_013520:1638000:1643188164318816446961509Veillonella parvula DSM 2008, complete genomeuroporphyrin-III C-methyltransferase2e-24112
NC_015172:3160249:3162009316200931635201512Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeuroporphyrinogen-III C-methyltransferase; uroporphyrinogen-III synthase2e-24112
NC_009633:74500:8262682626841341509Alkaliphilus metalliredigens QYMF chromosome, complete genomeuroporphyrin-III C-methyltransferase5e-23108
NC_014622:4361553:4373647437364743752031557Paenibacillus polymyxa SC2 chromosome, complete genomeuroporphyrin-III C-methyltransferase4e-21102
NC_013316:3863728:3876506387650638780051500Clostridium difficile R20291, complete genomeporphyrin biosynthesis protein includes: uroporphyrinogen-III methyltransferase and uroporphyrinogen-III synthase]5e-2098.2
NC_009089:3998347:4011102401110240126101509Clostridium difficile 630, complete genomeporphyrin biosynthesis protein9e-2097.4
NC_011146:482440:4851734851734867051533Geobacter bemidjiensis Bem, complete genomeuroporphyrin-III C-methyltransferase1e-1997.1
NC_014973:4630132:4654483465448346560211539Geobacter sp. M18 chromosome, complete genomeuroporphyrin-III C-methyltransferase2e-1995.9
NC_015942:3185193:318618231861823186970789Acidithiobacillus ferrivorans SS3 chromosome, complete genomeUroporphyrinogen III synthase HEM46e-1994.4
NC_008593:1917118:1935693193569319371861494Clostridium novyi NT, complete genomeuroporphyrinogen III synthase/methyltransferase6e-1891.3
NC_014314:404315:4269484269484284621515Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeuroporphyrin-III C-methyltransferase1e-1790.1
NC_015425:2144639:2161426216142621629221497Clostridium botulinum BKT015925 chromosome, complete genomeuroporphyrinogen III synthase/methyltransferase7e-1580.9
NC_016627:2023750:2045568204556820470701503Clostridium clariflavum DSM 19732 chromosome, complete genomeuroporphyrinogen-III C-methyltransferase, uroporphyrinogen-III synthase1e-1480.1
NC_014633:442755:4798304798304813021473Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceuroporphyrinogen-III C-methyltransferase ;uroporphyrinogen-III synthase8e-1477.4
NC_004557:749330:7537637537637552201458Clostridium tetani E88, complete genomeuroporphyrinogen III synthase/methyltransferase8e-1374.3
NC_015275:3976631:3985204398520439867211518Clostridium lentocellum DSM 5427 chromosome, complete genomeuroporphyrin-III C-methyltransferase9e-1373.9
NC_010001:1702350:1710625171062517121331509Clostridium phytofermentans ISDg, complete genomeuroporphyrin-III C-methyltransferase1e-1273.9
NC_014328:3482980:3496789349678934982491461Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeporphyrin biosynthesis protein HemD3e-1272.4
NC_013517:1055854:1107342110734211088231482Sebaldella termitidis ATCC 33386, complete genomeuroporphyrin-III C-methyltransferase4e-1272
NC_016627:4203775:4215875421587542174041530Clostridium clariflavum DSM 19732 chromosome, complete genomeuroporphyrin-III C-methyltransferase9e-1270.9
NC_015687:95918:1065551065551080271473Clostridium acetobutylicum DSM 1731 chromosome, complete genomeuroporphyrinogen III syntase1e-1170.5
NC_003030:95918:1065551065551080271473Clostridium acetobutylicum ATCC 824, complete genomeUroporphyrinogen III syntase1e-1170.5
NC_017295:95919:1065561065561080281473Clostridium acetobutylicum EA 2018 chromosome, complete genomeUroporphyrinogen III syntase1e-1170.5
NC_016791:1132451:1145059114505911465731515Clostridium sp. BNL1100 chromosome, complete genomeuroporphyrin-III C-methyltransferase2e-1170.1
NC_015636:1477221:147773314777331478503771Methanothermococcus okinawensis IH1 chromosome, complete genomeUroporphyrinogen-III synthase1e-1066.6
NC_002944:4446083:4464404446440444660621659Mycobacterium avium subsp. paratuberculosis K-10, complete genomeCysG6e-1064.7
NC_009635:61344:799617996180701741Methanococcus aeolicus Nankai-3 chromosome, complete genomeuroporphyrinogen III synthase HEM48e-1064.3
NC_011565:385454:3873133873133893612049Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase1e-0963.5
NC_010612:1005778:1008565100856510102411677Mycobacterium marinum M, complete genomeuroporphyrin-III C-methyltransferase HemD2e-0963.2
NC_020133:942375:9614829614829631581677Mycobacterium liflandii 128FXT, complete genomeuroporphyrin-III C-methyltransferase HemD2e-0963.2
NC_011898:1558208:1581797158179715833111515Clostridium cellulolyticum H10, complete genomeuroporphyrin-III C-methyltransferase5e-0961.6
NC_010730:180000:200670200670201383714Sulfurihydrogenibium sp. YO3AOP1, complete genomeUroporphyrinogen III synthase HEM42e-0859.7
NC_014734:3086165:311147931114793112282804Paludibacter propionicigenes WB4 chromosome, complete genomeuroporphyrinogen iii synthase hem46e-0857.8
NC_014958:514225:5312245312245326961473Deinococcus maricopensis DSM 21211 chromosome, complete genomeuroporphyrin-III C-methyltransferase9e-0857.4
NC_015519:488550:4969474969474984761530Tepidanaerobacter sp. Re1 chromosome, complete genomeuroporphyrin-III C-methyltransferase2e-0756.6
NC_009012:2953638:2996125299612529976061482Clostridium thermocellum ATCC 27405, complete genomeuroporphyrin-III C-methyltransferase1e-0653.5