Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:749330 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7482067493331128aminotransferase cobDQuickGO ontologyBLASTP
749330750055726cobalt transport protein CbiMQuickGO ontologyBLASTP
750314751024711cobalt transport protein cbiQQuickGO ontologyBLASTP
7510727522711200glutamyl-tRNA reductaseQuickGO ontologyBLASTP
752229752960732precorrin-2 dehydrogenaseQuickGO ontologyBLASTP
753094753750657porphobilinogen deaminaseQuickGO ontologyBLASTP
7537637552201458uroporphyrinogen III synthasemethyltransferaseQuickGO ontologyBLASTP
755228756217990delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
7562107574781269glutamate-1-semialdehyde aminotransferaseQuickGO ontologyBLASTP
7574917588101320cobyrinic acid AC-diamide synthaseQuickGO ontologyBLASTP
758813759469657precorrin-8X methylmutaseQuickGO ontologyBLASTP
7594747605531080cobalt-precorrin-6A synthaseQuickGO ontologyBLASTP
7605677617811215precorrin-6B methylasedecarboxylase cbiTcbiEQuickGO ontologyBLASTP
761774762439666precorrin-2 methyltransferaseQuickGO ontologyBLASTP
762457763227771precorrin-3 methylaseQuickGO ontologyBLASTP
763231764226996cobalamin biosynthesis protein CbiGQuickGO ontologyBLASTP
764247764972726precorrin-3B C17-methyltransferaseQuickGO ontologyBLASTP
764990765760771precorrin-6x reductaseQuickGO ontologyBLASTP
765853766359507hypothetical proteinBLASTP
766346767098753hypothetical proteinBLASTP
767134767937804anaerobic cobalt chelatase cbiKQuickGO ontologyBLASTP
768061768597537cobIyrinic acid ac-diamide adenosyltransferaseQuickGO ontologyBLASTP
768888769277390ferredoxin-like proteinQuickGO ontology
769281769817537cobIyrinic acid ac-diamide adenosyltransferaseQuickGO ontologyBLASTP