Pre_GI Gene

Some Help

Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4252000 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
425212042534961377ribonuclease RneRng familyQuickGO ontologyBLASTP
42535794254439861stage IV sporulation protein FBQuickGO ontologyBLASTP
42544324255178747stage IV sporulation protein FAQuickGO ontologyBLASTP
42553124256109798septum site-determining protein MinDQuickGO ontologyBLASTP
42561124256798687septum formation inhibitorQuickGO ontologyBLASTP
42568344257379546rod shape-determining protein MreDQuickGO ontologyBLASTP
42573944258245852rod shape-determining protein MreCQuickGO ontologyBLASTP
425828742593061020rod shape-determining protein MreBQuickGO ontologyBLASTP
42594654260142678DNA repair protein RadCQuickGO ontologyBLASTP
42601894260764576Maf-like proteinQuickGO ontologyBLASTP
42609854261947963stage II sporulation protein B putativeQuickGO ontologyBLASTP
426211342634141302folylpolyglutamate synthaseQuickGO ontologyBLASTP
426350842661532646valyl-tRNA synthetaseQuickGO ontologyBLASTP
426654942675741026hypothetical proteinBLASTP
42676374268620984stage VI sporulation protein D putativeQuickGO ontologyBLASTP
426873042700191290glutamate-1-semialdehyde aminotransferaseQuickGO ontologyBLASTP
42700194271008990delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
42710294271781753uroporphyrinogen-III synthetaseQuickGO ontologyBLASTP
42717834272712930porphobilinogen deaminaseQuickGO ontologyBLASTP
42727284273561834hemX proteinQuickGO ontologyBLASTP