Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4252000 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
425214742535381392ribonuclease RneRng familyQuickGO ontologyBLASTP
42536064254466861stage IV sporulation protein FBQuickGO ontologyBLASTP
42544594255205747stage IV sporulation protein FAQuickGO ontologyBLASTP
42553394256136798septum site-determining protein MinDQuickGO ontologyBLASTP
42561394256825687septum formation inhibitorQuickGO ontologyBLASTP
42568614257406546rod shape-determining protein MreDQuickGO ontologyBLASTP
42574214258272852rod shape-determining protein MreCQuickGO ontologyBLASTP
425831442593331020rod shape-determining protein MreBQuickGO ontologyBLASTP
42594924260169678DNA repair protein RadCQuickGO ontologyBLASTP
42602164260791576Maf-like proteinQuickGO ontologyBLASTP
42610124261974963putative stage II sporulation protein BQuickGO ontologyBLASTP
426214042634411302tetrahydrofolylpolyglutamate synthaseQuickGO ontologyBLASTP
426353542661802646valyl-tRNA synthetaseQuickGO ontologyBLASTP
426657642676011026spore coat protein YsxEQuickGO ontologyBLASTP
42676644268647984stage VI sporulation protein DQuickGO ontologyBLASTP
426875742700461290glutamate-1-semialdehyde aminotransferaseQuickGO ontologyBLASTP
42700464271035990delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
42710564271808753uroporphyrinogen-III synthaseQuickGO ontologyBLASTP
42718104272739930porphobilinogen deaminaseQuickGO ontologyBLASTP
42727554273588834hemX proteinQuickGO ontologyBLASTP