Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4251789 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
42517894252133345hypothetical proteinBLASTP
4252145425245330950S ribosomal protein L21QuickGO ontologyBLASTP
425261942540101392ribonuclease RneRng familyQuickGO ontologyBLASTP
42540784254938861stage IV sporulation protein FBQuickGO ontologyBLASTP
42549314255677747stage IV sporulation protein FAQuickGO ontologyBLASTP
42558114256608798septum site-determining protein MinDQuickGO ontologyBLASTP
42566114257297687septum formation inhibitorQuickGO ontologyBLASTP
42573334257878546rod shape-determining protein MreDQuickGO ontologyBLASTP
42578934258744852rod shape-determining protein MreCQuickGO ontologyBLASTP
425878642598051020rod shape-determining protein MreBQuickGO ontologyBLASTP
42599644260641678DNA repair protein RadCQuickGO ontologyBLASTP
42606884261263576Maf-like proteinQuickGO ontologyBLASTP
42614844262446963stage II sporulation protein B putativeQuickGO ontologyBLASTP
426261242639131302folylpolyglutamate synthaseQuickGO ontologyBLASTP
426400742666522646valyl-tRNA synthetaseQuickGO ontologyBLASTP
426704842680731026hypothetical proteinBLASTP
42681364269119984stage VI sporulation protein D putativeQuickGO ontologyBLASTP
426922942705181290glutamate-1-semialdehyde aminotransferaseQuickGO ontologyBLASTP
42705184271507990delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
42715284272280753uroporphyrinogen-III synthetaseQuickGO ontologyBLASTP
42722824273211930porphobilinogen deaminaseQuickGO ontologyBLASTP
42732274274060834hemX proteinQuickGO ontologyBLASTP