Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016512: Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

NCBI: NC_016512

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1151024157626475Island text1.6386726.459833.1968Neighbours11BLASTN+15102.gbk
230524032821222973Island text1.6667524.01245.578Neighbours11BLASTN305240.gbk
367968870347123784Island text2.4351825.570449.1392Neighbours11BLASTN+679688.gbk
4843938*87868934752Island text1.5713623.616940.6749Neighbours11BLASTN+843938.gbk
51211653123539623744Island text1.9518827.986647.0531Neighbours11BLASTN1211653.gbk
61357225*137794020716Island text1.9271125.919144.0443BLASTN+1357225.gbk
71810625183117120547Island text2.4816332.315737.5128Neighbours11BLASTN+1810625.gbk
82322598*234859926002Island text1.9637427.532946.3889Neighbours11BLASTN+2322598.gbk
92388612241135922748Island text2.050630.289646.223Neighbours11BLASTN+2388612.gbk
102506898*253349926602Island text1.6371324.322141.2576Neighbours11BLASTN2506898.gbk