Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:843938 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
843938845434149730S ribosomal protein S1QuickGO ontologyBLASTP
8456558470581404HtaAQuickGO ontologyBLASTP
8471808482831104hemin receptorQuickGO ontologyBLASTP
8482808493411062Heme ABC transporter permease protein HmuUQuickGO ontologyBLASTP
849338850117780Heme ABC transporter ATPase component HmuVQuickGO ontologyBLASTP
8501208518501731ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
8518478535171671ABC-type transport system fused ATPase and permeaseQuickGO ontologyBLASTP
853546854253708dephospho-CoA kinaseQuickGO ontologyBLASTP
8551178563431227htaaQuickGO ontologyBLASTP
856803857783981magnesium chelatase subunit ChlIQuickGO ontologyBLASTP
8577858595871803ATPase family associated with various cellular activities AAAQuickGO ontologyBLASTP
859587860000414hypothetical proteinBLASTP
8601568639893834CobNmagnesium chelatase domain proteinQuickGO ontologyBLASTP
863986864795810ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
8647978658401044iron chelate uptake ABC transporter permeaseQuickGO ontologyBLASTP
865837866406570periplasmic binding proteinQuickGO ontologyBLASTP
867342867491150hypothetical proteinBLASTP
867577867852276ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
867943868251309hypothetical proteinBLASTP
868265868810546permeaseQuickGO ontologyBLASTP
868797869594798hypothetical proteinBLASTP
870380870661282hypothetical proteinBLASTP
8708368729412106excinuclease ABC subunit BQuickGO ontologyBLASTP
873135874124990TerC family integral membrane proteinQuickGO ontologyBLASTP
874133874789657Zn-dependent hydrolaseQuickGO ontologyBLASTP
874835875578744mycothiol-dependent maleylpyruvate isomeraseQuickGO ontologyBLASTP
8757298786892961excinuclease ABC subunit AQuickGO ontologyBLASTP