Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:679688 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6779676796971731dihydroxyacetone kinaseQuickGO ontologyBLASTP
679688680191504phosphoribosyl transferase domain proteinQuickGO ontologyBLASTP
680281680781501GNAT family acetyltransferaseQuickGO ontologyBLASTP
6811456826921548NADP transhydrogenase subunit alphaQuickGO ontologyBLASTP
6826966841171422NADP transhydrogenase subunit betaQuickGO ontologyBLASTP
684263684583321ferredoxin family proteinQuickGO ontologyBLASTP
6845806856831104N-succinyldiaminopimelate aminotransferaseQuickGO ontologyBLASTP
685684686526843lipoproteinQuickGO ontologyBLASTP
6866246875869632345-tetrahydropyridine-26-dicarboxylate N-succinyltransferaseQuickGO ontologyBLASTP
6879676890971131glycine amidinotransferaseQuickGO ontologyBLASTP
6892216902821062hypothetical proteinBLASTP
6902926915931302prolinebetaine transporterQuickGO ontologyBLASTP
691606692097492transcriptional regulator TetR family proteinQuickGO ontologyBLASTP
6923386934171080succinyl-diaminopimelate desuccinylaseQuickGO ontologyBLASTP
693462693767306DivIVA domain-containing proteinQuickGO ontologyBLASTP
693808693975168hypothetical proteinBLASTP
6940396952231185glycogen synthaseQuickGO ontologyBLASTP
6953676965931227glucose-1-phosphate adenylyltransferaseQuickGO ontologyBLASTP
696676697329654O-methyltransferaseQuickGO ontologyBLASTP
697399698280882dihydrodipicolinate synthaseQuickGO ontologyBLASTP
698331698744414sec-independent translocaseQuickGO ontologyBLASTP
6988977004711575endoglycoceramidaseQuickGO ontologyBLASTP
7005277016871161mrp family proteinQuickGO ontologyBLASTP
701749702264516hypothetical proteinBLASTP
7022577034711215hypothetical proteinBLASTP