Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:1810625 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18106251811464840bifunctional biotin--acetyl-CoA-carboxylase synthetasebiotin operon repressorQuickGO ontologyBLASTP
18115961811967372hypothetical proteinBLASTP
181206018136341575propionyl-CoA carboxylase subunit betaQuickGO ontologyBLASTP
18136311813861231hypothetical proteinBLASTP
18138631814504642Maf-like proteinQuickGO ontologyBLASTP
18150791815498420hypothetical proteinBLASTP
18157551816429675short chain dehydrogenaseQuickGO ontologyBLASTP
18165331817336804bifunctional hydroxy-methylpyrimidine kinase hydroxy-phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
18174561818316861hypothetical proteinBLASTP
18182951818765471dicarboxylate carrier MatC domain proteinQuickGO ontologyBLASTP
181949718208431347hypothetical proteinBLASTP
18210341822032999magnesium transport proteinQuickGO ontologyBLASTP
18220291822421393NUDIX family hydrolaseQuickGO ontologyBLASTP
182279618245651770phosphoribosylglycinamide synthetaseQuickGO ontologyBLASTP
18245921825344753hypothetical proteinBLASTP
182538318267621380flavoprotein disulfide reductaseQuickGO ontologyBLASTP
18269511827763813putative purine nucleotide phosphorylaseQuickGO ontologyBLASTP
182779018294661677phosphoglucomutasephosphomannomutase alphabetaalpha domain IIQuickGO ontologyBLASTP
182949818311711674AMP-binding proteinQuickGO ontologyBLASTP