Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:305240 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
305240306052813hypothetical proteinBLASTP
306070306555486phosphoglycerate mutase family proteinQuickGO ontologyBLASTP
306603307592990acetyl xylan esterase AXE1QuickGO ontologyBLASTP
3076083086541047hypothetical proteinBLASTP
308732309286555inorganic pyrophosphataseQuickGO ontologyBLASTP
3094133107861374D-alanyl-D-alanine carboxypeptidaseD-alanyl-D-alanine-endopeptidaseQuickGO ontologyBLASTP
310786311721936hypothetical proteinBLASTP
311749312303555hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
3124453145982154cell division protein FtsHQuickGO ontologyBLASTP
314669315238570GTP cyclohydrolase IQuickGO ontologyBLASTP
315311315604294hypothetical proteinBLASTP
316951317589639hypothetical proteinBLASTP
317793318317525hypothetical proteinBLASTP
318440318799360hypothetical proteinBLASTP
318989319963975hypothetical proteinBLASTP
320106320522417hypothetical proteinBLASTP
320578321423846dihydropteroate synthaseQuickGO ontologyBLASTP
321484321846363dihydroneopterin aldolaseQuickGO ontologyBLASTP
3218433224005582-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinaseQuickGO ontologyBLASTP
322397322933537hypothetical proteinBLASTP
323028323693666hypothetical proteinBLASTP
3237703249601191NADH dehydrogenaseQuickGO ontologyBLASTP
325099325416318hypothetical proteinBLASTP
3256783282122535negative regulator of genetic competence ClpCMecBQuickGO ontologyBLASTP