Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:15102 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1510216070969L-lactate dehydrogenaseQuickGO ontologyBLASTP
16588175951008transcriptional regulatorQuickGO ontologyBLASTP
17592190971506ABC transporterQuickGO ontologyBLASTP
1918020157978ribose ABC transporterQuickGO ontologyBLASTP
2020621147942periplasmic sugar-binding proteinQuickGO ontologyBLASTP
2114422073930sugar kinaseQuickGO ontologyBLASTP
2207022453384D-ribose pyranaseQuickGO ontologyBLASTP
2305723533477PTS system galactitol-specific transporter subunit IIAQuickGO ontologyBLASTP
23590248461257PTS system galactitol-specific transporter subunit IICQuickGO ontologyBLASTP
2486725169303PTS system galactitol-specific transporter subunit IIBQuickGO ontologyBLASTP
2515925542384alcohol dehydrogenaseQuickGO ontologyBLASTP
25817277091893HTH domain proteinQuickGO ontologyBLASTP
2863528850216hypothetical proteinBLASTP
2932629481156hypothetical proteinBLASTP
2985230496645phosphataseQuickGO ontologyBLASTP
3048330695213hypothetical proteinBLASTP
3068531371687DeoR family transcriptional regulatorQuickGO ontologyBLASTP
3199032727738hypothetical proteinBLASTP
33394344521059putative aminotransferaseQuickGO ontologyBLASTP
3445635286831phospholipaseQuickGO ontologyBLASTP
3538635952567acetyltransferaseQuickGO ontologyBLASTP
3596636625660hypothetical proteinBLASTP
3704337516474hypothetical proteinBLASTP
3751638334819hypothetical proteinBLASTP
38331398091479type IIIV secretion system proteinQuickGO ontologyBLASTP
3980640681876type II secretion system F domain proteinQuickGO ontologyBLASTP
4067441576903type II secretion system F domain proteinQuickGO ontologyBLASTP