Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:1211653 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
121165312136922040beta-lactamaseQuickGO ontologyBLASTP
12137911214438648hypothetical proteinBLASTP
12144481215320873transcriptional regulatorQuickGO ontologyBLASTP
12154461216360915N-acetylmuramic acid 6-phosphate etheraseQuickGO ontologyBLASTP
121638012178971518phosphotransferase system EIICQuickGO ontologyBLASTP
12179011218347447hypothetical proteinBLASTP
12183281219272945BadFBadGBcrABcrD ATPase family proteinQuickGO ontologyBLASTP
121926912202791011Tat twin-arginine translocation pathway signal sequenceQuickGO ontologyBLASTP
122027612217061431glycosyl hydrolase family proteinQuickGO ontologyBLASTP
12217341222045312PTS system LactoseCellobiose specific IIB subunitQuickGO ontologyBLASTP
122204212233191278putative PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
12233161223681366PTS system LactoseCellobiose specific IIA subunitQuickGO ontologyBLASTP
122464612282183573DNA polymerase III subunit alphaQuickGO ontologyBLASTP
12282151228769555hypothetical proteinBLASTP
122879212300931302bifunctional histidinal dehydrogenase histidinol dehydrogenaseQuickGO ontologyBLASTP
123009012312561167histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
12312531231873621imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
12318661232483618imidazole glycerol phosphate synthase glutamine amidotransferase subunitQuickGO ontologyBLASTP
12324961233263768phosphoribosyl isomerase AQuickGO ontologyBLASTP
12334131234207795hypothetical proteinBLASTP
12342041234794591Crossover junction endodeoxyribonuclease RuvCQuickGO ontologyBLASTP
12347911235396606Holliday junction DNA helicase RuvAQuickGO ontologyBLASTP