Pre_GI Gene

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Host: NC_016512 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016512:2388612 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
238861223906812070NAD synthetaseQuickGO ontologyBLASTP
2390842239310622656-phosphofructokinaseQuickGO ontologyBLASTP
239317323942851113alanine dehydrogenaseQuickGO ontologyBLASTP
239458123960711491D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
23970212397152132hypothetical proteinBLASTP
239737623985871212secreted lipoproteinQuickGO ontologyBLASTP
239885824003241467lipoproteinQuickGO ontologyBLASTP
240061924019051287citrate Si-synthaseQuickGO ontologyBLASTP
240216224031691008adenosine deaminaseQuickGO ontologyBLASTP
240321624043281113alanine dehydrogenaseQuickGO ontologyBLASTP
24045022405017516AsnC family transcriptional regulatorQuickGO ontologyBLASTP
24053022405568267hypothetical proteinBLASTP
240580224068451044dihydrodipicolinate reductaseQuickGO ontologyBLASTP
24068572407204348hypothetical proteinBLASTP
240720124086221422threonine synthase cystathionine beta-synthaseQuickGO ontologyBLASTP
24086222409044423hypothetical proteinBLASTP
240904124113592319D-ornithine aminomutase E componentQuickGO ontologyBLASTP