Pre_GI: BLASTP Hits

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Query: NC_017179:3222015:3231633 Clostridium difficile BI1, complete genome

Start: 3231633, End: 3232610, Length: 978

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3214063:322368132236813224658978Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit C0663
NC_010674:2930259:2939551293955129405521002Clostridium botulinum B str. Eklund 17B, complete genomeATP synthase (C/AC39) subunit3e-57222
NC_010723:2735196:2743864274386427448651002Clostridium botulinum E3 str. Alaska E43, complete genomeATP synthase (C/AC39) subunit3e-56219
NC_008593:841291:8509748509748519751002Clostridium novyi NT, complete genomeATP synthase (C/AC39) subunit1e-55217
NC_014209:2257316:2269300226930022703041005Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,H+transporting two-sector ATPase C (AC39) subunit2e-54213
NC_013921:2375900:2387882238788223888861005Thermoanaerobacter italicus Ab9 chromosome, complete genomeH+transporting two-sector ATPase C (AC39) subunit5e-53208
NC_010321:2319820:2330442233044223314461005Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit C3e-52205
NC_014964:2301835:2312457231245723134611005Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeH+transporting two-sector ATPase C (AC39) subunit3e-52205
NC_010320:2397395:2409694240969424106981005Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit C4e-52205
NC_014538:2396559:2408858240885824098621005Thermoanaerobacter sp. X513 chromosome, complete genomeH+transporting two-sector ATPase C (AC39) subunit4e-52205
NC_009697:2680607:2689665268966526906661002Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit C2e-51202
NC_014377:2033781:2056069205606920570731005Thermosediminibacter oceani DSM 16646 chromosome, complete genomeH+transporting two-sector ATPase C (AC39) subunit1e-50200
NC_015425:906969:9165789165789175791002Clostridium botulinum BKT015925 chromosome, complete genomeATP synthase (C/AC39) subunit1e-49197
NC_012563:2979147:2990817299081729918181002Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, C subunit2e-49196
NC_013192:815854:825787825787826785999Leptotrichia buccalis DSM 1135, complete genomeH(+)-transporting two-sector ATPase4e-48192
NC_008261:2117207:2127848212784821288551008Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, C subunit3e-47189
NC_008262:1795914:1801899180189918029061008Clostridium perfringens SM101, complete genomeV-type ATPase, C subunit2e-47189
NC_003366:1901898:1912538191253819135451008Clostridium perfringens str. 13, complete genomeATP synthase subunit C4e-47188
NC_016148:1021138:1021138102113810221511014Thermovirga lienii DSM 17291 chromosome, complete genomeH+transporting two-sector ATPase C (AC39) subunit2e-24113
NC_009785:130252:1371111371111381241014Streptococcus gordonii str. Challis substr. CH1, complete genomeATP synthase (C/AC39) subunit9e-2097.8
NC_015562:627000:6351986351986363641167Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATP synthase subunit C2e-1893.2
NC_014122:393856:4043954043954055401146Methanocaldococcus infernus ME chromosome, complete genomeATP synthase A1, C subunit1e-1790.9
NC_009635:61344:6959969599707501152Methanococcus aeolicus Nankai-3 chromosome, complete genomeV-type ATP synthase subunit C1e-1584.3
NC_013407:1610221:1617223161722316184221200Methanocaldococcus vulcanius M7, complete genomeATP synthase A1, C subunit3e-1582.8
NC_015636:1477221:1487791148779114888761086Methanothermococcus okinawensis IH1 chromosome, complete genomeV-type ATP synthase subunit C8e-1581.3
NC_009637:302881:3124033124033135781176Methanococcus maripaludis C7 chromosome, complete genomeV-type ATP synthase subunit C3e-1479.7
NC_009634:411599:4214914214914226631173Methanococcus vannielii SB chromosome, complete genomeV-type ATP synthase subunit C3e-1479.7
NC_013156:431795:4406204406204418191200Methanocaldococcus fervens AG86, complete genomeATP synthase A1, C subunit4e-1479.3
NC_009135:494949:5047695047695059441176Methanococcus maripaludis C5, complete genomeH+-transporting two-sector ATPase, C (AC39) subunit3e-1479.3
NC_009975:1500978:1510213151021315113881176Methanococcus maripaludis C6, complete genomeATP synthase A1, C subunit4e-1479
NC_000909:201000:2093152093152105141200Methanocaldococcus jannaschii DSM 2661, complete genomeV-type ATP synthase subunit C6e-1478.6
NC_015847:1119666:1129331112933111305061176Methanococcus maripaludis XI chromosome, complete genomeV-type ATP synthase subunit C8e-1478.2
NC_005791:1028500:1035217103521710363921176Methanococcus maripaludis S2, complete genomeV-type ATP synthase subunit C1e-1377.4
NC_015574:2057602:2067410206741020685671158Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATP synthase subunit C3e-1376.3
NC_015216:405657:4132334132334143901158Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATP synthase subunit C5e-1168.9
NC_014222:186876:1951521951521963181167Methanococcus voltae A3 chromosome, complete genomeATP synthase A1, C subunit9e-1167.8
NC_003413:181525:1892171892171903291113Pyrococcus furiosus DSM 3638, complete genomeV-type ATP synthase subunit C7e-1065.1
NC_012883:1603744:1615303161530316164121110Thermococcus sibiricus MM 739, complete genomeA1A0 ATP synthase, subunit C1e-0964.3
NC_012804:141914:1408171408171419171101Thermococcus gammatolerans EJ3, complete genomeArchaeal/vacuolar-type H+ ATPase, subunit C (atpC)1e-0964.3
NC_000868:1730820:1742727174272717438391113Pyrococcus abyssi GE5, complete genomeV-type ATP synthase subunit C8e-0961.6
NC_014507:245344:2459382459382469961059Methanoplanus petrolearius DSM 11571 chromosome, complete genomeATP synthase A1 subunit C1e-0757.8
NC_013741:1390823:1398243139824313992651023Archaeoglobus profundus DSM 5631, complete genomeATP synthase A1, C subunit6e-0755.1
NC_019977:828427:8502258502258513041080Methanomethylovorans hollandica DSM 15978, complete genomeATP synthase A1, C subunit1e-0654.3